gbraliou@dib.uth.gr
+30 22310 66736

Contact with students:
Monday, Thursday, Friday 11.00 -13.00

 

 

Braliou Georgia

Assistant Professor

Molecular Biology and Genetic Epidemiology

Research Interests

Τranscriptional regulation of gene expression, transcription factors such as nuclear hormone receptors, hypoxia inducible factor (HIF), contribution of genetic polymorphisms to the etiology of multifactorial human diseases, genetic association studies of SNPs with diseases, meta-analysis of genetic association studies, GWAS, microarrays and RNAseq.

 

 

Curriculum vitae

Dr Braliou received her University degree in the field of Chemistry from the University of Athens. In May 1995 was accepted as a PhD student in the European Molecular Biology Laboratories (EMBL) in Heidelberg Germany. In November 1996 she moved to University of Nijmegen the Netherlands following her supervisor, Prof Henk Stunnenberg, and received her PhD diploma in the field of Molecular Biology /Biochemistry at January 2001.

The research of Dr Braliou is focused on two main directions. In the first one which covers mostly Molecular Biology and Biochemistry her focus is on transcriptional regulation of gene expression by molecules that exert their action in the nucleus such as nuclear hormone receptors,  hypoxia inducible factor or other transcription factors and co-factors, to elucidate mechanisms underlying diseases. In the second field, which covers mostly the area of Genetic Epidemiology her interest is in the contribution of genetic polymorphisms in the aetiology of multifactorial human diseases. With the case-control design applied in genetic association studies, she investigates SNPs implicated in the aetiology of diseases. In the same line, she also uses meta-analysis of genetic-association studies and GWASs in an effort to detect weak genotype-disease associations that most case-control studies do not have the power to detect. Finally, molecular biology techniques can be applied to the variants identified in order to elucidate mechanisms that underlie their action.

Since 2003, she serves in the University of Thessaly as a adjunct assistant professor/lecturer teaching ‘Molecular Basis of Genetic Diseases’, ‘Population Genetics’, ‘Genetic Epidemiology’, ‘Biology’, ‘Biochemistry’ and  ‘Clinical Biochemistry’ ‘Molecular Biology and Genetics’ at under- and post-graduate level in the Departments of ‘Biochemistry & Biotechnology’ and of ‘Computer Science & Biomedical Informatics’. Since 2018 she serves as assistant professor of Molecular Biology and Genetic Epidemiology in the department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.

Until today, her publication record includes:

  • 13 articles in Journals with referees, with 273 citations and h-index:   7 
  • 50 abstracts in Conferences Proceedings books
  • 3 Lab books
  • 1 patent
  • She has been supervising 32 diploma thesis of students.

Dr Braliou speaks English fluently and German and Dutch moderately.

 

 

 

Courses

Selected publications

  • Dimou NL, Pantavou KG, Braliou GG, Bagos PG. ‘Multivariate Methods for Meta-analysis of Genetic Association Studies’. Methods Mol Biol. 2018, 1793:157-182. doi: 10.1007/978-1-4939-7868-7_11.
  • Braliou GG, Pantavou KG, Kontou PI, Bagos PG. ‘Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis’. International Journal of Molecular Sciences, 2015, 16, 12368-81.
  • Braliou GG, Grigoriadou AM, Kontou PI, Bagos PG. ‘The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis’. Computational & Structural Biotechnology Journal, 2014, 10, 1-7.
  • Braliou G.G., Verga Falzacappa M.V., Chachami, G., Casanovas G., Muckenthaler M. U., and Simos, G. ‘2-oxoglutarate-dependent oxygenases control hepcidin gene expression’. Journal of Hepatology 2008, 48, 801-10.
  • Braliou G.G.*, Venieris, Ε.*, Kalousi, A., and Simos, G. ‘Reconstitution of human Hypoxia Inducible Factor (HIF-1) in yeast cells: a simple in vivo system to identify and characterize HIF-1α effectors’. Biochemical and Biophysical Research Communications, 2006, 346, 1289-1296. (*: equal contribution).